Tim Thomas Selected Research

Histone Acetyltransferases (Histone Acetyltransferase)

3/2015	MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.
7/2014	Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ.
9/2012	MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome.
12/2011	An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.
9/2011	Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.
10/2009	MYST family histone acetyltransferases take center stage in stem cells and development.
5/2006	Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells.

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Tim Thomas Research Topics

Disease

7	Leukemia 01/2019 - 05/2006
5	Neoplasms (Cancer) 01/2020 - 10/2009
2	Intellectual Disability (Idiocy) 01/2018 - 10/2007
2	DiGeorge Syndrome (Syndrome, DiGeorge) 07/2015 - 09/2012
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2015 - 05/2006
1	Nervous System Diseases (Neurological Disorders) 01/2022
1	Prostatic Neoplasms (Prostate Cancer) 01/2022
1	Nocturia 01/2021
1	Virus Diseases (Viral Diseases) 01/2019
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Lymphoma (Lymphomas) 01/2018
1	Infections 01/2016
1	Holt-Oram syndrome 07/2015
1	Genetic Translocation (Chromosomal Translocation) 03/2015
1	Down Syndrome (Down's Syndrome) 07/2014
1	Necrosis 04/2012
1	Myeloid Leukemia (Leukemia, Myelocytic) 12/2011
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 09/2011
1	Blepharoptosis (Ptosis, Eyelid) 09/2011
1	Inborn Genetic Diseases (Disease, Hereditary) 09/2011
1	Noonan Syndrome (Female Pseudo-Turner Syndrome) 09/2011
1	Trisomy (Trisomies) 07/2010
1	Obesity 10/2007
1	Hypoxia (Hypoxemia) 01/2004
1	Neural Tube Defects (Exencephaly) 12/2003
1	Spinal Dysraphism (Spina Bifida) 12/2003

Drug/Important Bio-Agent (IBA)

7	Histone Acetyltransferases (Histone Acetyltransferase)IBA 03/2015 - 05/2006
5	Proteins (Proteins, Gene)FDA Link 01/2018 - 05/2006
4	Transcription Factors (Transcription Factor)IBA 01/2019 - 09/2011
2	Lysine AcetyltransferasesIBA 01/2020 - 01/2016
2	Histones (Histone)IBA 10/2019 - 09/2012
2	InterferonsIBA 01/2019 - 07/2014
2	ChromatinIBA 07/2014 - 09/2012
1	General Transcription FactorsIBA 01/2022
1	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 01/2021
1	Interferon Type IIBA 01/2019
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 01/2019
1	2- Fluoro- N'- (3- fluoro- 5- (pyridin- 2- yl)benzoyl)benzenesulfonohydrazideIBA 01/2018
1	2-(phenylsulfonyl)hydrazide 4-fluoro-5-methyl- (1,1'-Biphenyl)-3-carboxylic acidIBA 01/2018
1	RNA Polymerase II (RNA Polymerase B)IBA 01/2018
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 09/2012
1	Type II Tumor Necrosis Factor ReceptorsIBA 04/2012
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 04/2012
1	TensinsIBA 01/2012
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2012
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 01/2012
1	Oxygen (Dioxygen)IBA 01/2004
1	UbiquitinIBA 01/2004
1	Ligases (Synthetase)IBA 01/2004
1	Inositol (Myoinositol)IBA 12/2003
1	Folic Acid (Vitamin M)FDA LinkGeneric 12/2003

Therapy/Procedure

1	Immunotherapy 01/2022
1	Contraindications 01/2021
1	Therapeutics 07/2010